Johns Hopkins Researchers Develop Human Stem Cell Line Containing Sickle Cell Anemia MutationResearchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. Publishing online in Stem Cells on May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies.Viropharma Announces Completion Of Enrollment In Phase 3 Study Of Maribavir In Stem Cell Transplant PatientsViroPharma Incorporated (Nasdaq: VPHM) announced that it completed enrollment in its pivotal Phase 3 study of maribavir in stem cell transplant patients. This international Phase 3 study is evaluating the efficacy, safety and tolerability of prophylactic use of maribavir administered orally for up to 12 weeks for the prevention of cytomegalovirus (CMV) disease in recipients of allogeneic stem cell transplants (SCT).Genomic Analysis Reveals New Insights Into Cellular ReprogrammingThe ability to drive somatic, or fully differentiated, human cells back to a pluripotent or "stem cell" state would overcome many of the significant scientific and social challenges to the use of embryo-derived stem cells and help realize the promise of regenerative medicine. Recent research with mouse and human cells has demonstrated that such a transformation ("reprogramming") is possible, although the current process is inefficient and, when it does work, poorly understood.Brainstorm Cell Therapeutics Chief Scientist, Dr. Daniel Offen, To Present Results From New Parkinson's Study At International Stem Cell MeetingBrainStorm Cell Therapeutics Inc. (OTCBB: BCLI), a leading developer of adult stem cell technologies and therapeutics, announced that Dr.Weill Cornell Team Identifies New Cancer Stem Cell Driving Metastatic TumorsThe molecular profile of cancer stem cells that initiate metastatic colon tumors is significantly different from those responsible for primary tumors, according to new research from a team at Weill Cornell Medical College. Cancer researchers have long believed that a protein called CD133 identifies a population of cancer stem cells (so-called CD133+ cells), the only subset of cells that are responsible for tumor initiation.Bone Repair Using Patient's Stem Cells Comes CloserHitherto it has been difficult to induce adult human stem cells to produce bone, e.g. in order to repair bone tissue. Researchers at the University of Twente have shown that if the enzyme PKA is previously activated in the stem cells in the lab, following implantation this results in substantial bone formation. This opens up new ways of repairing bone tissue using cell material from the patient.GOP Primary Candidates For U.S. Senate Seat In N.M. Differ On Stem Cell Research ViewsThe AP/Las Cruces Sun-News on Wednesday examined how Reps. Steve Pearce (R-N.M.) and Heather Wilson (R-N.M.) have differing views and voting records on legislation related to human embryonic stem cell research. Pearce and Wilson are competing for the Republican nomination for one of New Mexico's U.S. Senate seats.New Self Contained Stem Cell Workstation Makes Atmospheric Control Easier - Ruskinn Launches SCI-tive WorkstationRuskinn has announced the launch of its innovative, Stem Cell Investigations total in vitro environment workstation - SCI-tive - specifically designed for both embryonic and adult stem cell isolation, optimisation, differentiation and incubation within a totally enclosed controlled culture environment. Working under controlled conditions is essential to ensure the cell differentiation process does not result in inappropriate cell types.Andalusian Scientists Study Fly's Ovary To Go Deeply Into Stem CellsA group of scientists of the Centro Andaluz de Biologia del Desarrollo (CABD) are trying to go further in the stem cells field as they study a type of fly called Drosophila melanogaster. The reproductive system of this insect will be a model to understand stem cells better and make progress in their future use to treat certain human pathologies. The Andalusian Ministry of Innovation, Science and Enterprise has financed this project with 218,000 euros as part of their program of excellence.Osiris Therapeutics Initiates Phase II Clinical Trial Evaluating Prochymal(TM) For Chronic Obstructive Pulmonary DiseaseOsiris Therapeutics, Inc. (NASDAQ:OSIR) announced the treatment of the first patients in a new Phase II clinical trial evaluating Prochymal, a mesenchymal stem cell (MSC) therapy, for moderate to severe Chronic Obstructive Pulmonary Disease (COPD). This trial marks the sixth indication for which Prochymal has been advanced into Phase II or later-stage clinical trials.How Stem Cells Decide What They'll BeHow does a stem cell decide what specialized identity to adopt - or simply to remain a stem cell? A new study suggests that the conventional view, which assumes that cells are "instructed" to progress along prescribed signaling pathways, is too simplistic.Method To Duplicate Primitive Stem Cells And Prevent Cell Differentiation Discovered At USCResearch from the University of Southern California (USC) has discovered a new mechanism to allow embryonic stem cells to divide indefinitely and remain undifferentiated. The study, which is published in the May 22 issue of the journal Nature, also reveals how embryonic stem cell multiplication is regulated, which may be important in understanding how to control tumor cell growth.
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