Stem Cell Sentry Sounds The Alarm To Maintain Balance Between Cancer And AgingLike a sentry guarding the castle walls, a molecular messenger inside adult stem cells sounds the alarm when it senses hazards that could allow the invasion of an insidious enemy: Cancer. The alarm bell halts the process of cell division in its tracks, preventing an error that could lead to runaway cell division and eventually, tumor formation.Conference Brings Together National Pediatrics Experts For Innovations In Pediatric MedicineIn the last decade, biomedical and research breakthroughs, notably in genetics and stem cells, have helped transform the care of children, improving diagnosis and treatment for numerous diseases. On Nov.Cancer-Like Response Triggered From Embryonic Stem Cells By Forsyth ScientistsScientists from The Forsyth Institute, working with collaborators at Tufts and Tuebingen Universities, have discovered a new control over embryonic stem cells' behavior. The researchers disrupted a natural bioelectrical mechanism within frog embryonic stem cells and trigged a cancer-like response, including increased cell growth, change in cell shape, and invasion of the major body organs.Stem Cells May Act As "Trojan Horse" To Deliver Gene Therapy To Injured Central Nervous SystemAmyotrophic lateral sclerosis (ALS) researchers at The Methodist Hospital in Houston have shown that transplanted bone marrow stem cells can attach themselves to injured areas in the brain or spinal cord, possibly providing a way to deliver future gene therapy. According to Dr. Stanley H. Appel's study published in the Oct.Discovery Of Fat-Regenerating 'Stem Cells' In MiceResearchers have identified stem cells with the capacity to build fat, according to a report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew themselves, transplants of the progenitor cells isolated from the fat tissue of normal mice can restore normal fat tissue in animals that are otherwise lacking it.Landmark Study Unlocks Stem Cell, DNA Secrets To Speed TherapiesIn a groundbreaking study led by an eminent molecular biologist at Florida State University, researchers have discovered that as embryonic stem cells turn into different cell types, there are dramatic corresponding changes to the order in which DNA is replicated and reorganized.New Properties Of Skin Stem CellsRecent research from the Swedish medical university Karolinska Institutet reveals completely new properties of the skin's stem cells - discoveries that contradict previous findings. The studies, which are published in Nature Genetics, show amongst other things, that hair follicle stem cells can divide actively and transport themselves through the skin tissue.Mesoblast Limited First Patients Treated With Adult Stem Cells For Congestive Heart FailureAustralia's regenerative medicine company, Mesoblast Limited (ASX:MSB)(PINK:MBLTY), today announced successful early safety results in the world's first clinical trial to use allogeneic, or "off-the-shelf", adult stem cells from an unrelated donor to treat patients with congestive heart failure. Safety data from the first seven patients enrolled in the Phase 2 trial by Mesoblast's US-based sister company Angioblast Systems Inc.Mitochondria And Tumor Formation In Stem Cells LinkedResearchers report on a previously unknown relationship between stem cell potency and the metabolic rate of their mitochondria - a cell's energy makers. Stem cells with more active mitochondria also have a greater capacity to differentiate and are more likely to form tumors. These findings, appearing in JBC, could lead to methods of enriching the best stem cells from a population for therapeutic use and may provide some insights into the role of stem cells in cancer.
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